Investigational Drugs for the Treatment of Postherpetic Neuralgia: Systematic Review of Randomized Controlled Trials

The pharmacological treatment of postherpetic neuralgia (PHN) is unsatisfactory, and there is a clinical need for new approaches. Several drugs under advanced clinical development are addressed in this review. A systematic literature search was conducted in three electronic databases (Medline, Web of Science, Scopus) and in the ClinicalTrials.gov register from 1 January 2016 to 1 June 2023 to identify Phase II, III and IV clinical trials evaluating drugs for the treatment of PHN. A total of 18 clinical trials were selected evaluating 15 molecules with pharmacological actions on nine different molecular targets: Angiotensin Type 2 Receptor (AT2R) antagonism (olodanrigan), Voltage-Gated Calcium Channel (VGCC) 2 subunit inhibition (crisugabalin, mirogabalin and pregabalin), Voltage-Gated Sodium Channel (VGSC) blockade (funapide and lidocaine), Cyclooxygenase-1 (COX-1) inhibition (TRK-700), Adaptor-Associated Kinase 1 (AAK1) inhibition (LX9211), Lanthionine Synthetase C-Like Protein (LANCL) activation (LAT8881), N-Methyl-D-Aspartate (NMDA) receptor antagonism (esketamine), mu opioid receptor agonism (tramadol, oxycodone and hydromorphone) and Nerve Growth Factor (NGF) inhibition (fulranumab). In brief, there are several drugs in advanced clinical development for treating PHN with some of them reporting promising results. AT2R antagonism, AAK1 inhibition, LANCL activation and NGF inhibition are considered first-in-class analgesics. Hopefully, these trials will result in a better clinical management of PHNTraining University Lecturers program (FPU21/02736) of the Spanish Ministry of Economy and Competitiveness (MINECO

Relación entre jarositas de ambientes naturales y sus análogos sintéticos

Depto. de Mineralogía y PetrologíaFac. de Ciencias GeológicasTRUEpu

Robust people detection by fusion of evidence from multiple methods

Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. V. Fernández-Carbajales, M. A. García, and J. M. Martínez, "Robust People Detection by Fusion of Evidence from Multiple Methods", in Ninth International Workshop on Image Analysis for Multimedia Interactive Services, 2008. WIAMIS 2008, p. 55-58.This paper describes and evaluates an algorithm for real-time people detection in video sequences based on the fusion of evidence provided by three simple independent people detectors. Experiments with real video sequences show that the proposed integration-based approach is effective, robust and fast by combining simple algorithms.This work is supported by Cátedra Infoglobal-UAM para “Nuevas tecnologías de vídeo aplicadas a la seguridad”, the Spanish Government (TEC2007- 65400 SemanticVideo) and the Comunidad de Madrid (S-050/TIC-0223 - ProMultiDis-CM)

Integrated valuation of semiarid Mediterranean agroecosystem services and disservices

Agroecosystems are anthropised ecosystems where human activities, mainly agricultural practices, affect the innate functioning, leading to the provision of agroecosystem services (AES) and disservices (AEDS). This study presents a novel and integrated economic valuation of the AES and AEDS provided in a water-scarce Mediterranean area (south-eastern Spain), using a discrete choice experiment. The results reveal the social demand for AES and the disutility of AEDS, as well as the non-linearity in marginal utility for some of these AES and AEDS. Food provision, temperature regulation, leisure and recreation and biodiversity are socially perceived as AES. The water supply for irrigation switches between AES and AEDS depending on its provision level, while groundwater pollution is conceived as one of the AEDS. The integrated non-market value of AES and AEDS reaches 794 €/ha/year for the entire agroecosystem. This work provides guidelines for policy makers in the design of socially supported agricultural policies.This work was supported by the Spanish Ministry of Science and Innovation [AGRISERVI: AGL2015-64411-R (MINECO/FEDER)] and the “Fundación Séneca – Region de Murcia” [20912/PI/18]. José A. Zabala acknowledges the financial support from the Spanish Ministry of Education and Personal Training [FPU 16/03473]

Spider diversity (Arachnida: Araneae) in two different coffee management systems and surrounding tropical forest during two contrasting seasons in Oaxaca, Mexico

This study focuses on species richness, abundance, diversity, and seasonal variation of spiders in two coffee plantations with different crop management and a portion of tropical forest in two municipalities of La Costa region of Oaxaca, Mexico, using manual collection, foliage beating and pitfall traps. We collected 2,210 spiders belonging to 35 families, 100 genera and 146 species. The inventory includes 51 new species records for Oaxaca. Completeness values for two estimators indicate that the level of representation of inventories range from 68.25% to 78.44%, and the proportion of singletons range from 33.72% to 38.14%. Spider abundance in the rainy season was significantly lower than during the dry season. Spider abundance in the Tropical Forest was significantly lower than Monoculture site with the foliage beating method. Polyculture was the site with the lowest spider abundance with the pitfall traps. Rarefaction curves did not show significant differences in species richness between the sites and seasons. Hutcheson t-test showed that spider diversity was significantly lower in Monoculture than Tropical Forest during the rainy season. This study contributes to the knowledge of the arachnofauna of Mexico and particularly of the state of Oaxaca.Este estudio se enfoca en la riqueza de especies, abundancia, diversidad y variación estacional de las arañas en dos cultivos de café con diferente manejo y una porción de bosque tropical en dos municipios de la región Costa de Oaxaca, México, utilizando la colecta manual, agitación del follaje y trampas de caída. Se recolectaron 2,210 arañas pertenecientes a 35 familias, 100 géneros y 146 especies. El inventario incluye 51 nuevos registros de especies para Oaxaca. Los valores de completitud de dos estimadores indican que el nivel de representación de los inventarios oscila entre el 68.25 % y el 78.44 %, mientras que la proporción de singletons fue de 33.72 % y 38.14 %. La abundancia de arañas en la estación lluviosa fue significativamente menor que durante la estación secas. La abundancia de arañas en el Bosque Tropical fue significativamente menor que en el Monocultivo con el método de agitación de follaje. El Policultivo fue el sitio con menor abundancia de arañas con el método de trampas de caída. Las curvas de rarefacción no mostraron diferencias significativas en la riqueza de especies entre los sitios y estaciones. La prueba t de Hutcheson mostró que la diversidad de arañas fue significativamente menor en el Monocultivo que en el Bosque Tropical durante la estación lluviosa. Este estudio contribuye al conocimiento de la aracnofauna de México y particularmente del estado de Oaxaca

Geoguía 3: El Distrito Minero de La Unión, plomo, zinc, plata y estaño en la Sierra de Cartagena

El distrito minero de La Unión (Murcia) es uno de los sitios de interés geológico y minero más importantes de España, y junto con los distritos de Mazarrón y Rodalquilar constituye un extraordinario ejemplo de la relación entre el magmatismo mioceno del SE de España, la tectónica y los procesos metalogénicos. El distrito de La Unión ocupa una superficie de unos 10 x 5 km que encierra la mayor concentración de mineralizaciones de Pb-Zn de las Béticas y una de las mayores de España

Electrophoretic versus dielectrophoretic nanoparticle patterning using optoelectronic tweezers

Currently, there is increasing interest from many scientific disciplines in the development of systems that are able to sort and arrange many objects in parallel at the nano-and micrometric scale. Among others, photovoltaic tweezers (PVT) are an optoelectronic technique for trapping and patterning nano-and micro-objects in accordance with an arbitrary light profile. In this work, the differential features of electro-and dielectrophoretic (EP and DEP) nanoparticle (NP) patterning using PVT are deeply investigated. The study is carried out through theory and experiments. The developed theory extends the applicability of a previously reported model to be able to compute EP potentials and to obtain numerical values for the EP and DEP potential energies. Two-dimensional patterns of charged and neutral aluminum NPs are fabricated on top of Fe:LiNbO3 crystals, and different light distributions and other experimental parameters (crystal thickness and NP concentration) are compared. Patterns of charged and neutral NPs show remarkable differences in both particle density distribution and fidelity to the original light profile. The observed different features between EP and DEP trapping are satisfactorily explained by the theoretical analysis. The results provide routes for the optimization of the NP arrangements for both regimes.This work is supported by the Spanish Ministerio de Economía y Competitividad under Grant No. MAT201457704-C3. J.F.M.-M. is partially supported by a fellowship of the Universidad Politécnica de Madrid (Grant No. RR01/2016

Problemario de dinámica

1 archivo PDF (150 páginas) ; 2a ed. 2000, 5a reimpresión 2003.El presente trabajo es la recopilación de las experiencias de los profesores del Area de Física, en la impartición de la Unidad de Enseñanza Aprendizaje Dinámica. Con el objetivo de: Proporcionar a los alumnos una guía rápida y completa sobre el contenido de la U.E.A, ayudar al profesor en la impartición de la U.E.A., particularmente en la realización de ejercicios y problemas de la misma; uniformar el contenido de la U.E.A. y por tanto el aprendizaje de los alumnos de los diferentes grupos de dicha U. E.A.; auxiliar a los alumnos en su preparación para presentar las evaluaciones tanto parciales como globales o de recuperación de Dinámica

Scientific, Educational, and Environmental Considerations Regarding Mine Sites and Geoheritage: A Perspective from SE Spain

Should abandoned mine sites be eligible for some official protection under the umbrella of geoconservation? Providing they have enough educational and scientific value, the answer is affirmative, and we suggest that they should be granted protection at the level of geoheritage sites. Some may see mining as an environmental disaster, but others, with a more geologically oriented mind, may perceive mining as a blessing. Mining unveils the geology, thus allowing a more comprehensive vision of geological features such as rock units, faults, minerals, etc. We analyze the advantages and disadvantages of abandoned mines and districts as geologic observational sites, through the analysis of two mining districts from SE Spain: Mazarrón and Cartagena–La Unión. We propose that if an abandoned mine site or district has enough geological value, not only the mining site but also the whole geologic block hosting the ore deposits should also be protected. In this respect, the Sierra de Cartagena, hosting the Cartagena– La Unión district, is a valuable geological asset where an important chapter of the Alpine and late Alpine geologic history of SE Spain is written